Respuesta:During the 19th century, research in infectious diseases and microbiology confirmed the "contagionist" theory of the disease, discarding the miasmatic theory, promoting the development of techniques to isolate the microorganisms that cause infections and discovering the disease transmission mechanisms. Given the difficulty of having animal models for various groups of diseases, experimentation in humans became necessary, including autoinoculation by researchers.
The history of research on yellow fever in Cuba is a paradigmatic and fundamental experience of public health and an example of the triumph of the infectious disease approach. However, the circumstances underlying scientific triumphs over the American plague tell a lesser-known story, characterized by sacrifice and heroism, from which arise the foundations of ethics in scientific research and the origin of modern informed consent.
Long before the Nuremberg Code, Walter Reed's research and Carlos Finlay's theories interacted to establish a historical milestone that led to the triumph of scientific medicine, and the origin of documentation and strict formalization of respect for the integrity of volunteers participating in the research
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